Here, you'll find support and helpful information, including tips to prepare for your next appointment, links to pain support organizations, and answers to common questions about Xtampza ER.
Talking with your doctor
You are the only one who can tell your doctor how your treatment is working for you. Remember to talk to your doctor about any questions or concerns you might have, so you can both be sure that your current treatment plan is meeting your needs.
4 tips to prepare for your next appointment:
Keep Track
Keep a journal of your pain, symptoms, activities, and any side effects you are experiencing. Bring the journal to your appointment so you can discuss what you’ve recorded.
Bring Support
Bring along a family member or friend for support. Your companion can help with providing information to your doctor or taking notes during your appointment.
Ask Questions
Write down any questions you might have about your pain, current treatment, or side effects.
Take Notes
Remember to take notes during your appointment so you can keep track of any directions or important information your doctor gives you.
Finding support
Suffering from any chronic condition can feel very isolating. Connecting with others who also live with chronic pain can be helpful in understanding your pain and how to manage it.
Below, you'll find organizations dedicated to educating and supporting those living with pain. Visit their sites to find support groups in your area as well as other helpful information.
*Collegium provides financial support to these organizations. Collegium Pharmaceutical, Inc. is not responsible for and does not create, control, or influence any of the content on any third-party website.
Frequently Asked Questions about Xtampza ER
Xtampza ER is a strong prescription pain medicine that contains an opioid (narcotic) that is used to manage severe and persistent pain that requires an extended treatment period with a daily opioid medicine, when other pain medicines do not treat your pain well enough or you cannot tolerate them.
“ER” stands for “extended release.” Extended-release opioids work for a long period of time because the medicine is released slowly in your body.
Xtampza ER is designed with DETERx® technology. This technology may help reduce problems like misuse or abuse.
- Misuse is when a medicine is used incorrectly (this can be on purpose or not)
- Abuse is when a medicine is used for a nonmedical purpose
The use of Xtampza ER, like all opioid medications, may result in serious risks of addiction, abuse, misuse, and life‑threatening or fatal respiratory depression, even when used as recommended.
Xtampza ER is taken twice daily and MUST be taken with food every 12 hours, at the same time every day. It is important to take each Xtampza ER dose with approximately the same amount of food because it helps the body properly absorb the medication.
Call your doctor if the dosage you are taking does not control your pain. Do not stop taking Xtampza ER or change your dose without talking to your doctor.
For further information about Xtampza ER, please see full Prescribing Information and the Medication Guide.
Xtampza ER can be taken in several ways that do not involve swallowing pills or capsules:
- Sprinkled on soft foods
- Sprinkled in a cup
- Taken through a feeding tube
If you have difficulty swallowing Xtampza ER capsules or have a preference about how to take your medication, let your doctor know and ask about your options.
Xtampza ER MUST be taken with food.
For further information about Xtampza ER, please see full Prescribing Information and the Medication Guide.
While taking Xtampza ER, do not drive or operate heavy machinery until you know how Xtampza ER affects you. Xtampza ER can make you sleepy, dizzy, or light-headed.
Do not drink alcohol or use prescription or over-the-counter medicines that contain alcohol. Using products containing alcohol during treatment with Xtampza ER may cause you to overdose and die.
For further information about Xtampza ER, please see full Prescribing Information and the Medication Guide.
Do not take Xtampza ER if you have severe asthma, trouble breathing, or other lung problems; if you have a bowel blockage or have narrowing of the stomach or intestines.
For further information about Xtampza ER, please see full Prescribing Information and the Medication Guide.
Before taking Xtampza ER, tell your healthcare provider if you have a history of:
- head injury, seizures
- liver, kidney, thyroid problems
- problems urinating
- pancreas or gallbladder problems
- abuse of street or prescription drugs, alcohol addiction, or mental health problems
Tell your healthcare provider if you are:
- noticing your pain getting worse. If your pain gets worse after you take XTAMPZA ER, do not take more of XTAMPZA ER without first talking to your healthcare provider. Talk to your healthcare provider if the pain you have increases, if you feel more sensitive to pain, or if you have new pain after taking XTAMPZA ER.
- pregnant or planning to become pregnant. Prolonged use of XTAMPZA ER during pregnancy can cause withdrawal symptoms in your newborn baby that could be life-threatening if not recognized and treated.
- breastfeeding. Not recommended during treatment with XTAMPZA ER. It may harm your baby.
- living in a household where there are small children or someone who has abused street or prescription drugs.
- taking prescription or over-the counter medicines, vitamins, or herbal supplements. Taking XTAMPZA ER with certain other medicines can cause serious side effects that could lead to death.
For further information about Xtampza ER, please see full Prescribing Information and the Medication Guide.
Xtampza ER was developed with abuse-deterrent technology to help address some of the issues relating to opioid use. However, abuse of Xtampza ER is still possible, and like all opioid medications, Xtampza ER comes with serious risks of addiction, abuse, misuse, and can be fatal. Talk to your doctor about your role in responsible pain management and how you can help keep your Xtampza ER prescriptions, and those around you, safe.
Remember to:
- Take Xtampza ER exactly as your doctor has prescribed and do not share with others
- Store all your medications safely and securely (such as in a locked box or cabinet)
- Discard unused medications properly and do not save them if they are no longer needed
For further information about Xtampza ER, please see full Prescribing Information and the Medication Guide.
If you’re eligible,* you may be able to save with an Xtampza ER Co-pay Card.
Please see Program Terms, Conditions, Eligibility Criteria, which include additional exclusions.
You can connect with others and find resources on chronic pain management through our list of chronic pain organizations. These organizations offer support and education to people living with pain and their family and friends.
INDICATIONS AND USAGE
XTAMPZA® ER (oxycodone) is:
- A strong prescription pain medicine that contains an opioid (narcotic) that is used to manage severe and persistent pain that requires an extended treatment period with a daily opioid medicine, when other pain medicines do not treat your pain well enough or you cannot tolerate them.
- A long-acting (extended-release) opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly as prescribed by your healthcare provider, you are at risk for opioid addiction, abuse, and misuse that can lead to death.
- Not to be taken on an "as needed" basis
IMPORTANT SAFETY INFORMATION ABOUT XTAMPZA ER
WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF XTAMPZA ER
Addiction, Abuse, and Misuse
Because the use of XTAMPZA ER exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient’s risk prior to prescribing and reassess all patients regularly for the development of these behaviors or conditions.
Life-Threatening Respiratory Depression
Serious, life-threatening, or fatal respiratory depression may occur with use of XTAMPZA ER, especially during initiation or following a dosage increase. To reduce the risk of respiratory depression, proper dosing and titration of XTAMPZA ER are essential.
Accidental Ingestion
Accidental ingestion of even one dose of XTAMPZA ER, especially by children, can result in a fatal overdose of oxycodone.
Risks From Concomitant Use With Benzodiazepines or Other CNS Depressants
Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of XTAMPZA ER and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.
Neonatal Opioid Withdrawal Syndrome (NOWS)
If opioid use is required for an extended period of time in a pregnant woman, advise the patient of the risk of NOWS, which may be life-threatening if not recognized and treated. Ensure that management by neonatology experts will be available at delivery.
Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS)
Healthcare providers are strongly encouraged to complete a REMS-compliant education program and to counsel patients and caregivers on serious risks, safe use, and the importance of reading the Medication Guide with each prescription.
Cytochrome P450 3A4 Interaction
The concomitant use of XTAMPZA ER with all cytochrome P450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in oxycodone plasma concentration. Regularly evaluate patients receiving XTAMPZA ER and any CYP3A4 inhibitor or inducer.
Important information about XTAMPZA ER:
- Get emergency help or call 911 right away if you take too much XTAMPZA ER (overdose). When you first start taking XTAMPZA ER, when your dose is changed, or if you take too much (overdose), serious life-threatening breathing problems that can lead to death may occur. Talk to your healthcare provider about naloxone, a medicine for the emergency treatment of an overdose.
- Taking XTAMPZA ER with other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.
- Taking XTAMPZA ER with other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.
- Never give anyone else your XTAMPZA ER. They could die from taking it. Selling or giving away XTAMPZA ER is against the law.
- Store XTAMPZA ER securely, out of sight and reach of children, and in a location not accessible by others, including visitors to the home.
Do not take XTAMPZA ER if you have:
- severe asthma, trouble breathing, or other lung problems.
- a bowel blockage, or have narrowing of the stomach or intestines.
Before taking XTAMPZA ER, tell your healthcare provider if you have a history of:
- head injury, seizures
- liver, kidney, thyroid problems
- problems urinating
- pancreas or gallbladder problems
- abuse of street or prescription drugs, alcohol addiction, opioid overdose, or mental health problems
Tell your healthcare provider if you are:
- noticing your pain getting worse. If your pain gets worse after you take XTAMPZA ER, do not take more of XTAMPZA ER without first talking to your healthcare provider. Talk to your healthcare provider if the pain you have increases, if you feel more sensitive to pain, or if you have new pain after taking XTAMPZA ER.
IMPORTANT SAFETY INFORMATION ABOUT XTAMPZA ER
WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF XTAMPZA ER
Addiction, Abuse, and Misuse
Because the use of XTAMPZA ER exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient’s risk prior to prescribing and reassess all patients regularly for the development of these behaviors or conditions.
Life-Threatening Respiratory Depression
Serious, life-threatening, or fatal respiratory depression may occur with use of XTAMPZA ER, especially during initiation or following a dosage increase. To reduce the risk of respiratory depression, proper dosing and titration of XTAMPZA ER are essential.
Accidental Ingestion
Accidental ingestion of even one dose of XTAMPZA ER, especially by children, can result in a fatal overdose of oxycodone.
Risks From Concomitant Use With Benzodiazepines or Other CNS Depressants
Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of XTAMPZA ER and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.
Neonatal Opioid Withdrawal Syndrome (NOWS)
If opioid use is required for an extended period of time in a pregnant woman, advise the patient of the risk of NOWS, which may be life-threatening if not recognized and treated. Ensure that management by neonatology experts will be available at delivery.
Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS)
Healthcare providers are strongly encouraged to complete a REMS-compliant education program and to counsel patients and caregivers on serious risks, safe use, and the importance of reading the Medication Guide with each prescription.
Cytochrome P450 3A4 Interaction
The concomitant use of XTAMPZA ER with all cytochrome P450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in oxycodone plasma concentration. Regularly evaluate patients receiving XTAMPZA ER and any CYP3A4 inhibitor or inducer.
- pregnant or planning to become pregnant. Prolonged use of XTAMPZA ER during pregnancy can cause withdrawal symptoms in your newborn baby that could be life‑threatening if not recognized and treated.
- breastfeeding. Not recommended during treatment with XTAMPZA ER. It may harm your baby.
- living in a household where there are small children or someone who has abused street or prescription drugs
- taking prescription or over‑the‑counter medicines, vitamins, or herbal supplements. Taking XTAMPZA ER with certain other medicines can cause serious side effects that could lead to death.
When taking XTAMPZA ER:
- Do not change your dose. Take XTAMPZA ER exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest time needed.
- Take your prescribed dose every 12 hours, at the same time every day. Do not take more than your prescribed dose. If you miss a dose, take your next dose at your usual time.
- If you cannot swallow XTAMPZA ER capsules, see the detailed Instructions for Use in the Medication Guide.
- Always take XTAMPZA ER capsules with approximately the same amount of food to ensure enough medicine is absorbed.
- Swallow XTAMPZA ER whole. Do not snort, or inject XTAMPZA ER because this may cause you to overdose and die.
- The contents of the XTAMPZA ER capsules may be sprinkled on soft food, sprinkled into a cup and then put directly into the mouth, or given through a nasogastric or gastrostomy tube.
- Call your healthcare provider if the dose you are taking does not control your pain.
- Do not stop taking XTAMPZA ER without talking to your healthcare provider.
- Dispose of expired, unwanted or unused XTAMPZA ER by promptly flushing down the toilet, if a drug take‑back option is not readily available. Visit www.fda.gov/drugdisposal for additional information on disposal of unused medicines.
While taking XTAMPZA ER, DO NOT:
- Drive or operate heavy machinery, until you know how XTAMPZA ER affects you. XTAMPZA ER can make you sleepy, dizzy, or light‑headed.
- Drink alcohol or use prescription or over‑the‑counter medicines that contain alcohol. Using products containing alcohol during treatment with XTAMPZA ER may cause you to overdose and die.
The possible side effects of XTAMPZA ER are:
- constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, and abdominal pain. Call your healthcare provider if you have any of these symptoms and they are severe.
Get emergency medical help or call 911 right away if you have:
- trouble breathing, shortness of breath, fast heartbeat, chest pain, swelling of your face, tongue, or throat, extreme drowsiness, light‑headedness when changing positions, feeling faint, agitation, high body temperature, trouble walking, stiff muscles, or mental changes such as confusion.
These are not all the possible side effects of XTAMPZA ER. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1‑800‑FDA‑1088. For more information, go to dailymed.nlm.nih.gov.
See full Prescribing Information, including Boxed Warning on Addiction, Abuse and Misuse and other serious risks, and the Medication Guide accompanying this piece or at XTAMPZAER.com/PI. Speak to your healthcare provider if you have questions about XTAMPZA ER.
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