Everyone experiences pain from time to time. But chronic pain doesn't go away. Healthcare providers define it as pain lasting longer than 3 months. Severe and persistent pain, a more intense subset of chronic pain, could be caused by a health condition or injury, and sometimes there's not an obvious cause.
If you are one of the millions of Americans suffering from severe and persistent pain, speak to your doctor to see if treatments such as XTAMPZA ER may be able to help you manage severe and persistent pain.
XTAMPZA ER is an oxycodone-based pain medication. Oxycodone has been used for many years to help manage severe and persistent pain that requires an extended treatment period with a daily opioid medicine, when other pain medicines do not treat your pain well enough or you cannot tolerate them. The "ER" in "XTAMPZA ER" stands for extended release, which means it delivers pain-relieving medication slowly over time.
Unlike immediate-release (IR) pain medicines that might provide short-term relief, XTAMPZA ER is an extended-release (ER) medication. XTAMPZA ER offers a dose of medication that lasts for a longer period of time in the body. ER formulations prolong pain relief over many hours, so fewer pills are needed each day. Most short-acting medications only work 4 to 6 hours at a time, which means you might have to take them up to 6 times a day. XTAMPZA ER is dosed every 12 hours, so you only take it twice a day. XTAMPZA ER should be taken at the same time every day and MUST be taken with food.
There are several ways you can take XTAMPZA ER that have been approved by the FDA. If you have difficulty or dislike swallowing pills, XTAMPZA ER has several options that may help.
Because the use of XTAMPZA ER exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient's risk prior to prescribing and reassess all patients regularly for the development of these behaviors and conditions.
Serious, life-threatening, or fatal respiratory depression may occur with use of XTAMPZA ER, especially during initiation or following a dosage increase. To reduce the risk of respiratory depression, proper dosing and titration of XTAMPZA ER are essential.
Accidental ingestion of even one dose of XTAMPZA ER, especially by children, can result in a fatal overdose of oxycodone.
Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of XTAMPZA ER and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.
If opioid use is required for an extended period of time in a pregnant woman, advise the patient of the risk of NOWS, which may be life-threatening if not recognized and treated. Ensure that management by neonatology experts will be available at delivery.
Healthcare providers are strongly encouraged to complete a REMS-compliant education program and to counsel patients and caregivers on serious risks, safe use, and the importance of reading the Medication Guide with each prescription.
The concomitant use of XTAMPZA ER with all cytochrome P450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in oxycodone plasma concentration. Regularly evaluate patients receiving XTAMPZA ER and any CYP3A4 inhibitor or inducer.
These are not all the possible side effects of XTAMPZA ER. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1‑800‑FDA‑1088. For more information, go to dailymed.nlm.nih.gov.
See full Prescribing Information, including Boxed Warning on Addiction, Abuse and Misuse and other serious risks, accompanying this piece or at XTAMPZAER.com/PI. Speak to your healthcare provider if you have questions about XTAMPZA ER.